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Interestingly, a recent study showed that oral supplementation of NR altered the intestinal microbial composition in rats and mice but not humans 63 , highlighting the need for further studies on this matter to assess the impact of NAD + metabolism modulation by the microbiome on health outcomes

For example, geranylgeranylacetone (GGA) has been reported to activate HSF1 and increase HSP90 expression in frozen sperm from male Chinese sturgeon, thereby helping preserve sperm quality (Xi et al., 2018)

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