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Regain begins within 4 to 6 weeks of last dose Appetite increases but remains below pre-treatment baseline Weight regain of 0.5 to 1 pound per week for 12 to 16 weeks, then plateau Patients report maintaining some dietary changes learned during treatment Net long-term outcome: retain 30 to 50% of weight lost on medication Typically occurs in patients who built structured meal patterns and exercise habits during treatment Pattern 3: Sustained maintenance without medication (approximately 15% of discontinuations)

Orally administered medications may experience altered absorption with delayed gastric emptying

This makes it easy for members to get their medications

This reflects earlier findings among people with type 2 diabetes who lost weight after intensive lifestyle interventions: those who lost more weight still had improved hemoglobin A1c levels (a measure of blood sugar) after four years, even after regaining all the weight

Take MASLD and OSA, for example

It effectively reduces postprandial glucose levels owing to a marked inhibitory effect on gastric emptying, and it also reduces fasting glucose levels and body weight