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Start your intake What the Long-Term Clinical Data Actually Shows The largest long-term semaglutide trial, SUSTAIN-5, tracked patients for 230 weeks (over 4 years) and found that gastrointestinal side effectsnausea, vomiting, constipationwere most common during dose escalation phases but declined significantly once patients stabilized on their maintenance dose

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This is one reason clinicians review the full medication list before making changes

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