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Philip Pape: 2:21 I want to give a special shout out to Michael Kay, one of our longtime listeners
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Safety profile in PIONEER trials: Nausea: 11% to 20% (dose-dependent) Diarrhea: 8% to 11% Vomiting: 5% to 9% Discontinuation due to GI side effects: 4% to 7% The side effect rates are lower than injectable semaglutide at weight-loss doses, likely because the systemic exposure is lower
This suggests that for retatrutide, the final maintenance dose may be more significant than the speed of reaching it
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Triozzi, M.D., an instructor in the Division of Nephrology and Hypertension and the studys first author, noted that these findings suggest GLP-1 receptor agonists could have broader kidney-protective effects that initially thought
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