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For instance, the majority (58%) of mouse microbiome studies published in 20182019 did not report the number of mice per cage, and less than 20% of studies reported using singly-housed animals 64

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Disruption of cysteine uptake and collapse of intracellular GSH pool induces an inhibition of the detoxifying activity of GPx4 and excessive accumulation of oxidatively damaged lipids at the membrane, although it remains unclear if this solely affects the cell plasma membrane, or the effect also extends to organelle membranes