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High Hcy levels are often caused by low intake or poor metabolism of vitamins B6, B9, and B12 (found in green vegetables and citrus) or by gene mutations that affect Hcy breakdown

As we have documented the tolerability of L-PAM+BSO when supported by autologous stem cell infusion in heavily pretreated relapsed and/or refractory neuroblastoma patients (NANT phase I study, NCT00005835, www.clinicaltrials.gov), using myeloablative L-PAM+BSO is clinically feasible

Special populations: dosing adjustments for age, kidney function, and prior bariatric surgery Age over 65: The STEP-1 trial included 12% of patients over age 65

Also, there are several studies that have proven its effectiveness in improving Parkinsons disease at 100 mg IG/kg b.w

Steady-state blood levels are typically reached by week 4-5 of treatment

Cell Viability Assay HepG2 cells were plated on collagen-coated 96-well plates at the density of 1 10 4 per well in 0.1 mL DMEM