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These chemical agents have a polycyclic, chain-like structure

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Psychiatry Res 317:114836 Borsini A, Merrick B, Edgeworth J, Mandal G, Srivastava DP, Vernon AC, Nebbia G, Thuret S, Pariante CM (2022) Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized Covid-19 patients with neurological symptoms

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Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells

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