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Nausea, vomiting, diarrhea, constipation, and stomach pain are the most common side effects
Acknowledgements This study was approved by the Alfred Hospital Ethics Committee (project number 463/18) and the Australian Institute of Health and Welfare Ethics Committee (EO2018/5/501)
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Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics
Furthermore, fibrotic remodelling within the synovial joint in rheumatoid arthritis and osteoarthritis [2,3] is considered a major driver of chronic pain and loss of mobility
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