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There is substantial evidence that the expression of SOCS3 protein increases with aging in several cells/tissues, such as rat myocardium [162], hypothalamus [163], and human blood mononuclear cells [164] as well as human sarcopenic skeletal muscles [165] and the brains of Alzheimers patients [166]

They secrete modulatory molecules, including prostaglandins, arachidonic acid and nitric oxide, which influence vessel diameter and blood flow in response to neuronal activity 8,18

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