Getting the dose right is important, as injecting too much can cause unpleasant side effects
In fact, some trials observed slight improvements in metabolic markers, likely secondary to fat loss rather than direct peptide effects
A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
Serum B12 alone can be misleading, while methylmalonic acid levels offer a more accurate assessment of whether the body is utilizing available B12
Thank you to all the doctors for making things so easy for us
pharmacological inhibition of NNMT has therefore become a major focus in laboratory research on adipose-tissue energy balance, methyl-donor recycling, and metabolic resilience