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Its selective GHS-R1a agonism producing GH release without cortisol or prolactin elevation makes it a valuable tool for investigating the growth hormone axis in isolation from other endocrine effects
The most common side effects of zonisamide include: dizziness and lightheadedness fatigue and drowsiness language and speech difficulty metallic taste nausea Other possible side effects include: trouble sleeping lack of coordination loss of appetite and weight loss diarrhea double vision mood changes such as depression or irritability difficulty concentrating These symptoms may subside after your body adjusts to the medication
Vierucci A, De Martino M, Graziani E, Rossi ME, London WT, Blumberg BS
The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction
Journal of Trace Elements in Medicine and Biology, 81 , 127338
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