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Companies, they want to make small molecule GLP-1 drugs

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We find that a wide range of different machine-learning approaches yield similar outcomes

10.1080/15548627.2021.1886829 172 Lu ZZ.JiC.LuoX.LanY.HanL.ChenY.et al (2021)

Cancer Cell 25 (3), 304317 (2014)

The standard titration schedule exists because GLP-1 receptor density in the gut exceeds that in the hypothalamus jumping from 0.25mg to 1.0mg semaglutide weekly without allowing four weeks at each intermediate dose causes severe nausea, vomiting, and discontinuation in 4050% of patients