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Liquid vs Tablets vs Sublingual vs B12 Injections A 2025 systematic review found that oral, sublingual, and intramuscular routes can all improve B12 status, but the certainty and comparability of the available studies vary
NICE recommends lifelong intramuscular replacement for vitamin B12 deficiency caused by autoimmune gastritis, or after total gastrectomy or complete terminal ileal resection
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Sikiri P et al
For a 180-pound (82 kg) person, that is roughly 100 to 130 grams per day
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins
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