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adolescents with obesity have a prediabetes glycemic profile (9, 10), with ~35% progressing to persistent dysglycemia or overt diabetes during adulthood (11)

Gastrointestinal adverse events induced by metformin are associated with dose escalation, immediate-release formulations, alterations in gut microbiota, epigenetic susceptibility, inhibition of organic cation transporters, as well as interactions with serotonin, histamine, and enterohepatic circulation [72]

Healthcare professionals play a vital role in supporting patients throughout their weight loss journey, providing guidance on the appropriate duration of treatment with weight loss medications and strategies for maintaining weight loss

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Converting everyday observations into clear, actionable patterns is essential for making informed treatment decisions

These limitations underscore the need for further mechanistic insights and innovative delivery strategies to fully harness neuroprotective potential of targeting Nrf2-mediated pathways