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10.1038/s41467-025-60844-9 8 BoutouyrieP.ChowienczykP.HumphreyJ

Glutathione has many important functions, including: making DNA, the building blocks of proteins and cells supporting immune function breaking down some free radicals helping certain enzymes function regenerating vitamins C and E assisting regular cell death (a process known as apoptosis) It also helpsthe liver and gallbladder deal with fats Researchers have found links between low levels of glutathione and some diseases

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These insights further support therapeutic exploration, with JAKSTAT inhibitors (Batra et al.) [88], IL-6 and HDAC inhibitors (Liao et al.) [86], and metabolic modulators targeting glycolysis and sphingosine metabolism (Lin et al.) [84] emerging as promising avenues

Similarly, serotonin levels are significantly lower in the model group, indicating a potential sleep disorder