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Because the dosing protocol used in clinical trials may not actually be the most biologically optimal approach

C.ChenZ

Oral Wegovy (not Rybelsus, which is a different formulation approved for diabetes) is a legitimate choice for patients with true needle phobia

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The SUSTAIN-6 study demonstrated a 26% reduction in major adverse cardiovascular events (MACE), which includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in high-risk patients with type 2 diabetes

Accordingly, these patients should be evaluated for orthostatic hypotension before starting therapy with a SGLT2i [11]