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For Medicare, this usually applies to prescription drugs

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The United States Preventive Services Task Force (USPSTF) reported that the accumulated data on nutritional supplements do not provide unambiguous conclusions for cancer prevention (Moyer 2014)

A notable example is the placebo-controlled trial by Bhasin et al., which demonstrated dose-dependent anabolic effects of supraphysiological testosterone enanthate administered for 10 weeks in healthy men, providing valuable mechanistic insight under rigorously controlled conditions but without addressing long-term safety outcomes (96)

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