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In the tubules, GLP1 induces a natriuretic effect, decreasing the activity and expression of sodium-glucose cotransporters type I and II (SGLT1/2) as well as reducing the activity of the NH3 exchanger through phosphorylation, leading to increased Na+ presence in the macula densa, restoring tubuloglomerular feedback with afferent vasoconstriction and reduction of intraglomerular pressures

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