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It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years, lead investigator Ania Jastreboff, MD, professor of medicine and pediatrics at the Yale School of Medicine and director of the Yale Obesity Research Center, said in a press release

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Ablation of the PPG neurons in the NTS largely reduces the level of GLP-1 in the hypothalamus, brainstem, and spinal cord (Williams, 2009)