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Semaglutide suppresses appetite through one channel

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J Biol Chem 277:4350511 Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H (2001) Activation of matrix metalloproteinases by peroxynitrite-induced protein S -glutathiolation via disulfide S -oxide formation

The Ipamorelin component activates the Gq-coupled GHS-R1a (ghrelin) receptor, mobilizing intracellular calcium and suppressing somatostatin tone