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Clin J Am Soc Nephrol 7:11121120

Even if each peptide has independent research support, the combination has not been studied for synergy, antagonism, pharmacokinetic interaction, or safety

NNMT uses up nicotinamide by tagging it with a methyl group (a process called methylation) and sending it out as waste

Inhibition of the Trx system by auranofin induced cell death (most likely ferroptosis) only in non-endocrine small cell lung cancer, whereas inhibition of the Grx system by buthionine sulfoximine killed specifically the endocrine cells [203]

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