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A 2021 Cochrane systematic review of GLP-1 receptor agonists for type 2 diabetes (including 21 trials with over 17,000 participants) confirmed that liraglutide reduced HbA1c by a mean of 1.01% (95% CI 0.84 to 1.18%) versus placebo and was associated with weight reduction rather than weight gain, distinguishing it from sulfonylureas [15]

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