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In people with type 2 diabetes, both the secretion and action are deficient of GLP-1
Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12
The mechanisms responsible for this dichotomy remain to be established
Milesi-Hall, A
Body composition shifts may begin by week 6 rather than week 8
Consistency (same day every week) is what matters most for efficacy
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