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Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1

doi:10.1074/jbc.274.50.35816

But you don't have to choose just one

Once in the system, the active ingredients are believed to encourage pigment-producing cells (melanocytes) to release more melanin

Yvette-Marie Pellegrino, a board-certified obesity medicine specialist with Beaufort Memorial Ladys Island Internal Medicine

For example, we need to gain more information on the regulation of GST expression during incompatible plant-pathogen interactions