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We recommend future research directions to determine when to start with SL, IM, or oral vitamin B12 in different situations

In SURMOUNT-1, 2,539 adults with obesity, or with overweight and at least one weight-related complication, excluding diabetes, were randomized to once-weekly tirzepatide at 5 mg, 10 mg or 15 mg or to placebo for 72 weeks including a 20-week escalation period

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