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Since cardiovascular complications of diabetes (62, 63) as well as diabetic nephropathy (64) are associated with an imbalance in the activity of RAAS, the interaction with this system could explain some of the beneficial effects of GLP1-RA

Four participants did not complete the trial: two because of their desire to use semaglutide after the first intervention rather than continue the study, one because of difficulty complying with the study procedures and one because of the side effects of 0.5 mg semaglutide (Fig

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