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Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)

The dosage gradually increases until it reaches the weight-loss dose of 2.4mg per week

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

Humans express a second BDH gene, BDH2, whose encoded protein is only 20% identical to the BDH1 encoded protein

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Apply light pressure with an alcohol pad after withdrawal if any bleeding occurs