These drugs mimic a natural gut hormone (GLP-1) that stimulates insulin secretion, slows digestion, and reduces appetite
Reduced L-carnitine transport in aortic endothelial cells from spontaneously [PMID: 24587332] Laboratory literature summary: Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats
Reagents GLP-1(736), GLP-1(936), exendin-4 and exendin(939) were from Bachem (Weil am Rhein, Germany), the glucagon receptor (GCGR) antagonist REMD2.59 was from REMD Bioptherapeutics (Camarillo, CA, USA) and pertussis toxin (PTX) was from Sigma (Gillingham, Dorset, UK)
This adds another five years of patent protection beyond the main compound patent
For weight management specifically, semaglutide (Wegovy, also approved for adolescents 12 years), liraglutide 3 mg (Saxenda), and tirzepatide (Zepbound) have received FDA approval
All experiments were performed in triplicate with fresh solutions prepared for each replica