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Other effects In addition to above effects, GLP-1R agonists have other neuroprotection mechanism on CNS, such as increasing the brain-derived neurotrophic factor (BDNF) levels and activity, regulating calcium homeostasis, promoting glycolysis, and reducing vascular damage
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In a previous Phase I trial, six patients treated with a single dose of NTLA-2001 showed significant reductions in serum TTR protein levels, with no serious adverse effects or liver damage reported
doi: 10.1016/j.cmet.2024.05.010 36
Luminescence values and enrichment scores were also reasonable predictors of full-length substrate cleavage activity: of the seven substrates that were cleaved, all but one ranked in the top 50th percentile of enrichment scores (Fig
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