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SGLT2 inhibitors provide substantial benefits for people with type 2 diabetes mellitus and either established HF or elevated HF risk [86]
Injectable semaglutide has the strongest evidence base, supported by Phase 3 trials and FDA approval pathways
The nausea associated with semaglutide is thought to result from both its effects on gastric emptying and its action on central nervous system centers involved in nausea and appetite regulation
Chronic activation of the HPA axis can lead to adrenal exhaustion and low adrenal hormone levels (Anderson 2008)
While this and other reported clinical experience have not identified differences in responses between the elderly and younger patients, greater sensitivity of some older individuals cannot be ruled out
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