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Moreover, this hypothesis agrees with results reported during the preparation of this manuscript that demonstrate that GLP-1R undergoes endocytosis independent of arrestin and is mediated by both clathrin- and caveolae-dependent mechanisms (Moo et al., 2025)

As with any medication, semaglutide works best as part of a broader health strategy that includes a balanced diet, regular physical activity, and routine check-ins with a healthcare provider

It's motivation to eat better and start exercising

doi: 10.1186/s12974-019-1638-6 38 NizariSBasalayMChapmanPKorteNKorsakAChristieINet al