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Furthermore, the onset of GI complications could limit or interfere with the recommended dose escalation up to 14 mg, which represents the dosage for which the maximum effectiveness of the product is appreciated

The authors concluded that berberine may clinically lower blood lipid and glucose levels via multi-target mechanisms, with one of the possible mechanisms being related to its effect on the SCFAs of the gut microbiota

However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)

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[12] Li, L., Hansch, M., Xu, Z., Yang, G., Zha, M., Wang, Y.,

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