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In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]
Retatrutide is not FDA-approved and is available only for research purposes
Patients interested in this kind of weight loss treatment should be aware that there are also severe medical issues such as gallbladder issues, heart disease, and kidney damage linked to this drug, making regular monitoring by healthcare providers highly important for anyone taking it long term
insulin degludec) and SURPASS-5 (vs
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