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Additionally, comparison between Gipr fl/fl vehicle and Gipr Syn/ vehicle groups revealed that reduced CNS GIPR function led to an overall decrease in gene expression related to immune response and inflammation, particularly within the neutrophil degranulation pathway, where serine peptidase inhibitor, clade A, member 3 M ( Serpina3m ), deoxyribose-phosphate aldolase ( Dera ), fatty acid binding protein 5 ( Fabp5 ), ATP citrate lyase ( Acly ) and cathepsin D ( Ctsd ) were downregulated