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Yusta and colleagues demonstrated that GLP-1 analogs suppress proinflammatory cytokine expression in IELs through cAMP-mediated signaling (84)

By modulating rather than eliminating the inflammatory response, both modalities support optimal healing conditions

The analyses revealed pathways peculiarly enriched, such as catecholamine biosynthesis, thyroid hormone synthesis, Warburg effect, pyruvate metabolism, gluconeogenesis in plasma, and butyrate metabolism, oxidation and branched chain fatty acids, mitochondrial electron transport chain, phytanic acid peroxisomal oxidation and TCA cycle in pericardial fluid

PMID: 41972905 J EthnopharmacolLiquiritigenin alleviates inflammation and mitochondrial dysfunction in acute pancreatitis via ER-VDAC1 signaling

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