do b12 injections work better than pills Vitamin vs. Oral Supplements: Which is Better? Vitamin B-12 Injections Vs Oral

How often you need a B12 injection depends on a few things

When NNMT is blocked, nicotinamide is redirected back into the NAD+ salvage pathway, increasing intracellular NAD+ concentrations approximately 2-fold in treated adipocytes

Paul C et al

Intramuscular B12 injections bypass the digestive tract entirely, ensuring full bioavailability where oral supplementation may be insufficient or ineffective

Depending on your levels of deficiency or energy needs, B12 injections are commonly given weekly or monthly

Assay-Dependent Potency IC 50 values require test conditions A value of approximately 1.2 M is commonly reported for NNMT inhibition under a specified in-vitro enzyme assay using defined substrate and SAM concentrations