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10.1016/j.jplph.2004.10.005 58 JimenezA.HernandezJ

2.2.2 Glutathione Peroxidase 4 (GPX4) and its role in ferroptosis GPX4 is a selenoprotein that plays a central role in suppressing ferroptosis by catalyzing the reduction of membrane-bound phospholipid hydroperoxides (PL-OOH) into their corresponding non-toxic alcohols (PL-OH), thereby preserving lipid bilayer integrity under oxidative stress (17)

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( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes

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Key Takeaway: Combining weight loss medications is a strategy sometimes used to bypass the bodys natural resistance to weight loss by targeting both the gut hormones and the central nervous system simultaneously