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The UK Chief Medical Officers' guidelines recommend at least 150 minutes of moderate-intensity aerobic activity weekly, plus muscle-strengthening activities on two or more days
Practical guidance for patients Share your full medical history, including liver or kidney conditions, with your prescriber
Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers
Dosing does not typically require gender-based adjustment, though individual response should always guide protocol modifications
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Resistance training and metabolic rate preservation Resistance training during GLP-1 therapy is not optional
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