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[4] An increase in cAMP levels may activate protein kinase A (PKA), which might, in turn, phosphorylate several proteins, such as the voltage-dependent calcium channels in the cell membrane.
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The reason for the greater increase in our study is presumably that excessive L-carnitine is excreted into the urine in mice, while in the medaka model, the compound was dissolved in the water in the tank, which allowed medakas to maintain higher L-carnitine levels
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