F.GolozoubovaV.RolinB.KnudsenL
Thus, glutamine metabolism is intriguingly linked with intricate cell metabolic processes via enzymes associated with mitochondrial glutaminolysis, cytosolic glutamine metabolism, and glutamine-derived metabolites that perform diverse cellular functions
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Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (34, 55)
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8 and 9), potentially due to the weaker interactions between Cagri and ECL3