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This yields the formation of the DNA adducts 4-OHE 2 -1-N7Gua and 4-OHE 2 -1-N3Ade via a Michael addition

[Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal opportunistic infections in mice]

2733, pubmed.ncbi.nlm.nih.gov/25559140/, Bruce, et al

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If conclusively proven, this may help to explain the rapid rise is diabetes and metabolic disturbances, and offer the possibility of more specifically treating the underlying dysfunctions