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However, the SOD activity on day 30 was still lower than that of the control (group 1) (Figure 4B)
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The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)
using 1,200 mg doses showed only 37.5% efficacy versus 18.7% placebo, with 32% of patients experiencing adverse events including liver dysfunction
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