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For our analysis, we set the false-positive filter value q at 0.2, and we fixed the predetermined constant c(V) at unity, following a conservative approach for assessing significance (as per Sathe et al., 2023)

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Bottom Line Despite some dizzying progress for this class of drugs, there are still so many unknowns (besides lack of explainability as already touched on)

Gly-Pro-Glu, the tripeptide removed to make DES, is not biological waste

While there is limited published data specifically examining intramuscular administration of tirzepatide, extrapolation from pharmacokinetic principles and experience with other subcutaneous medications suggests several potential concerns

Its not just an operational question or a supply chain question