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According to the STEP clinical trials referenced in NICE TA875, patients treated with Wegovy achieved substantial weight loss, typically in the range of 10-15% of initial body weight over 68 weeks of treatment when combined with lifestyle interventions

By stimulating insulin release and suppressing glucagon secretion (a hormone released by the liver that increases glucose in the bloodstream), GLP-1s contribute to reduced blood sugar levels

Weight management is not just about losing weight

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Additionally, GLP-1 agonists significantly reduce food intake

One of the first signs of this was the weight loss reported by patients using GLP-1 drugs for their diabetes