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WS-917 binds ABCB1, stimulates its ATPase activity, and reverses resistance by increasing intracellular paclitaxel by 730-fold, with low toxicity and synergy with CD8 + T-cell responses

Jet lag disorder is a recognised circadian rhythm sleep-wake disorder (CDC Yellow Book 2026) whose symptoms include impaired concentration and memory, because crossing time zones forces the brain to work during its biological night