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The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]
We also observed that mean enrichment of a substrate decreases monotonically with increasing Hamming distance to procaspase-1, consistent with our hypothesis that cleavage activity on single-residue substitutions is predictive of cleavage activity on higher-order combinations of substitutions (Supplementary Fig
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While GLP-1based therapy is safe for many individuals, it may not be suitable for everyone
Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age
Presented for research literature review only Misra S (2024)
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