What This Means for Women in Midlife If you're considering a GLP-1 medication for weight management, the question isn't just "which medication?" it's "what else is going on hormonally?" For women in perimenopause or postmenopause, addressing estrogen deficiency may: Enhance the weight loss response to GLP-1 medications [1] Improve the metabolic benefits including better insulin sensitivity and reduced visceral fat [7, 8] Address symptoms like sleep disruption, hot flashes, and mood changes that can undermine weight loss efforts [10] Support long-term cardiovascular health during a period of accelerated risk [9] This is why a comprehensive approach one that evaluates both your metabolic health and your hormonal status matters so much more than choosing a single medication in isolation
The pharmacokinetics, dose-response, safety, and outcomes data for this use are minimal in published literature
Chandy thinks the phenomenon occurs because the B12 allows the body to put itself right, and if you have had things wrong for a long time, then theres a lot to put right in a small period of time
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However, just because the body can make its own glutathione doesn't mean it's always able to maintain adequate levels of this vital molecule