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It is important to emphasize that oral semaglutide is initiated at a sub-therapeutic dose (3 mg daily) for the first 30 days to improve gastrointestinal tolerability

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FOR ORFORGLIPRON TABLETS SOURCE: MedlinePlus

Studies suggest that various molecular pathways are involved in IC/BPS, including the JUN N-terminal kinase (JNK) pathway, transient receptor potential (TRP) channels, activated mast cells, mucosal signalling, circadian rhythm regulation, inflammation and neural dysregulation

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