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What the Clinical Evidence Shows While large-scale randomized controlled trials specifically measuring testosterone as a primary endpoint in tirzepatide users are still emerging, the available evidence is encouraging: The SURMOUNT trials demonstrated average weight losses of 15-22.5% of body weight, a degree of fat reduction strongly associated with testosterone recovery in men with obesity-related hypogonadism (Jastreboff et al., 2022, NEJM )
Individual timelines vary based on starting dose, metabolism, and adherence to nutrition and exercise recommendations
Recently, a new trend of prescribing vitamin B12 with semaglutide has emerged in medical spas and weight loss clinics
How GLP-1 Medications Work GLP-1 receptor agonists help regulate blood sugar, slow digestion, and reduce appetite
Stephen Matta
30 , 157173.e157 (2019)
