It acts like natural GLP-1, connecting to the same receptors, but it stays in the body much longer than the hormone would, according to clinical data reviewed by the National Library of Medicine
A prospective observational study by Zhu et al
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AOD-9604 AOD-9604 is primarily recognized for its potential to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the transformation of non-fatty foods into body fat)
But until then, tirzepatide is the only dual-agonist option available outside of clinical trials
While Ozempic is FDA-approved for type 2 diabetes and offers added weight loss benefits, compounded semaglutide lacks FDA approval and is no longer widely available following the resolution of a semaglutide shortage in March 2025